KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
26.23
Human Site:
S869
Identified Species:
44.4
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S869
K
M
L
I
N
G
E
S
G
Q
A
K
R
N
_
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S869
K
M
L
I
N
G
E
S
G
Q
A
K
R
N
_
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S869
K
M
L
I
N
G
E
S
G
Q
A
K
R
N
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
S859
K
M
L
L
N
G
E
S
S
Q
G
K
R
D
_
Rat
Rattus norvegicus
O54735
833
94538
S827
K
T
L
L
N
G
E
S
G
Q
A
K
R
D
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S857
K
N
L
I
N
G
E
S
N
Q
P
K
R
N
_
Chicken
Gallus gallus
P52731
862
99990
D853
G
G
G
G
G
G
E
D
G
K
S
K
T
C
I
Frog
Xenopus laevis
NP_001088271
859
97399
K849
K
N
L
V
N
G
D
K
S
Q
S
E
V
N
C
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
G846
W
K
I
L
A
E
Q
G
E
E
A
A
L
L
N
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
S873
R
Q
H
D
H
G
A
S
V
P
A
S
P
C
S
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
S1153
E
V
A
V
D
S
P
S
E
K
A
S
V
N
G
Honey Bee
Apis mellifera
XP_394107
1016
115998
S998
A
P
E
D
A
A
K
S
T
K
A
L
I
P
D
Nematode Worm
Caenorhab. elegans
P91119
710
81117
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
G918
E
G
S
R
S
T
G
G
G
E
P
K
K
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
71.4
78.5
N.A.
78.5
26.6
40
6.6
20
20
13.3
0
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
85.7
92.8
N.A.
78.5
46.6
66.6
33.3
33.3
60
26.6
0
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
15
8
8
0
0
0
58
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
8
% C
% Asp:
0
0
0
15
8
0
8
8
0
0
0
0
0
15
8
% D
% Glu:
15
0
8
0
0
8
50
0
15
15
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
15
8
8
8
65
8
15
43
0
8
0
0
0
15
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
29
0
0
0
0
0
0
0
0
8
0
8
% I
% Lys:
50
8
0
0
0
0
8
8
0
22
0
58
8
0
0
% K
% Leu:
0
0
50
22
0
0
0
0
0
0
0
8
8
8
0
% L
% Met:
0
29
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
50
0
0
0
8
0
0
0
0
43
8
% N
% Pro:
0
8
0
0
0
0
8
0
0
8
15
0
8
8
0
% P
% Gln:
0
8
0
0
0
0
8
0
0
50
0
0
0
0
0
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
0
43
8
0
% R
% Ser:
0
0
8
0
8
8
0
65
15
0
15
15
0
0
8
% S
% Thr:
0
8
0
0
0
8
0
0
8
0
0
0
8
0
0
% T
% Val:
0
8
0
15
0
0
0
0
8
0
0
0
15
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
43
% _